Isonville is an unincorporated town in Elliott County, Kentucky. It lies along Routes 32 and 486 east of the city of Sandy Hook, the county seat of Elliott County. Its elevation is 709 feet. Although it is unincorporated, it has a post office, closed in 2012/13 with the ZIP code of 41149.

Isonville was found in 1866 and named for Archibald Ison, an early settler from Virginia.